JACC Adv. 2024 Aug 24;3(10):101211. doi: 10.1016/j.jacadv.2024.101211. eCollection 2024 Oct.
PMID: 39263415 PMCID: PMC11388744 DOI: 10.1016/j.jacadv.2024.101211
Abstract
The patent ductus arteriosus is a very common condition in preterm infants, and a hemodynamically significant patent ductus arteriosus increases morbidity and mortality in these vulnerable patients. However, despite numerous randomized controlled trials, there is no consensus regarding management. Medical therapy is typically offered as first-line treatment, although it yields limited success and carries the potential for severe adverse events. In recent years, there has been rapid development in transcatheter patent ductus arteriosus closure primary with the use of the Amplatzer Piccolo Occluder, and this has gained widespread acceptance as a safe and effective alternative to surgical ligation in extremely low-birth-weight infants weighing over 700 g. This article aims to provide an appraisal of the patient selection process, a step-by-step procedural guide, and a comprehensive review of the outcomes associated with this approach.
Keywords: echocardiography; extremely low birth weight infants; outcomes; patent ductus arteriosus; premature infant.